Microbial therapeutic enzymes: A promising area of biopharmaceuticals

Overview of Microbial Therapeutic Enzymes

The enzyme technology is applied to pharmaceutical research, development and manufacturing and is a growing field. Therapeutic enzymes have been in use for around at least 40 years. For example, a therapeutic enzyme was described as a part of replacement therapies for genetic deficiencies in 1960s by de Duve (Vellard, 2013). Attempts are made to capitalize on the advantages of enzymes as drugs ...

Microbial Quality Concerns for Biopharmaceuticals

Apelin: A promising therapeutic target? (Part 1)

Apelin is a recently discovered bioactive peptide, known to be an endogenous high-affinity ligandfor the previously orphan G protein-coupled receptor APJ. Apelin/APJ as a novel signaling pathwayhas been shown to play many crucial roles in cardiovascular function, blood pressure regulation, fluidhomeostasis, feeding behavior, obesity, type 2 diabetes mellitus, adipoinsular axis regulation, cellp...

Sources, Properties and Applications of Microbial Therapeutic Enzymes

Enzymes or biocatalysts are produced in the human body from amino acids that the body obtains by digesting food proteins. Enzymes accelerate and control all biochemical processes in the body and in a single second several millions of enzyme mediated chemical reactions occur in a human body. Each enzyme is programmed to carry out one special task. The immense number of enzymes acts as a perfectl...

Yessotoxin, a Promising Therapeutic Tool

Yessotoxin (YTX) is a polyether compound produced by dinoflagellates and accumulated in filter feeding shellfish. No records about human intoxications induced by this compound have been published, however it is considered a toxin. Modifications in second messenger levels, protein levels, immune cells, cytoskeleton or activation of different cellular death types have been published as consequenc...